Kymberly has managed many chronic illnesses for 25+ years, including sciatica, costochondritis, fibromyalgia, PTSD, endometriosis, and more.
What Is Endometriosis?
Endometriosis affects around 1 in 10 women worldwide, and it can be a debilitating disease. Pain, heavy menstruation, and infertility are the most common symptoms.
Although the cause is not yet known, this condition occurs when the endometrial cells, normally lining the uterus and shed during a period, grow in places they shouldn't:
- inside the abdomen, outside the uterus;
- on the bladder or bowel walls;
- on the outside surface of the ovaries and fallopian tubes;
- and less commonly, on the outside surface of the liver, kidneys, and diaphragm.
These endometrial lesions bleed during menstruation, leaking blood into places where it shouldn't be, causing scars and adhesions to form—in turn causing more pain.
It Doesn’t Go Away
Endometriosis is a chronic disease—it doesn't disappear if you ignore it.
In fact, it can become very serious when the endometrial cells invade muscle walls (adenomyosis) or other organs in the abdomen.
Please, don't ignore period pain or heavy bleeding—get it checked out.
Mine turned into level 4 (extreme) endometriosis and severe adenomyosis. It developed to this stage because I was told the pain was 'normal' and to 'just put up with it' for seven years.
A hysterectomy is also not a cure. The endometriosis cells outside of the uterus will still grow with the remaining estrogen you have, even if you have your ovaries removed. Although, a hysterectomy does cure adenomyosis, a related disease.
Most doctors recommend a combination of laparoscopic surgery to remove the existing growths and medication treatments to control further growth of the endometrial lesions, although surgery for endometriosis is often kept as a last resort if medications fail.
No one knows what causes endometriosis, why some patients have extreme growths, or why others have no pain. Both the medical and natural health communities are still searching for answers. No cure for this condition has been discovered, only medications and therapies that may help manage the symptoms.
I am not a doctor or pharmacist, although I have extensive experience with endometriosis and adenomyosis (see notes in each section below). Please see your doctor for a diagnosis and appropriate treatment.
The following medications are often prescribed to endo patients to both ease the symptoms and control the growth of endometriosis.
Read More From Patientslounge
Note: None of these medications cure endometriosis; they only treat and control the symptoms. There is no current cure.
I've listed them in order from treating mild cases to strong medications for extreme cases.
Most Common Endometriosis Medications
|Pain control||Mild endo - Estrogen and progestin||Moderate endo - Progestin only||Severe endo - Menopause inducing|
Daily birth control tablets
Daily tablets (Visanne)
3 month injections (Lupron)
Weekly birth control patches or rings
Injections (Depo-provera) or impants (Implanon)
1 month implant injections (Zoladex)
Stronger prescription pain medications
Progestin-containing IUD (Mirena)
- NSAIDs such as ibuprofen, or stronger medications, are often prescribed to help reduce the pain and the inflammation associated with bleeding into spaces where blood shouldn't exist.
Long-term use of anti-inflammatory medications can damage the stomach lining and kidneys, so they are not recommended for continuous use.
- Paracetamol (acetaminophen, Tylenol) or other mild pain medications are also recommended to reduce the pain during menstruation.
These pain medications only mask the symptoms; they do not act on the endometriosis growths.
Treating Mild Endometriosis
Birth Control Pills to Slow the Growth
When initially searching for a diagnosis, to control period pain (dysmenorrhea) and heavy or long bleeding (hypermenorrhea), birth control is often prescribed.
Most standard birth control medications contain both estrogen and progestin (synthetic progestogen) in varying amounts.
High estrogen pills should be avoided by endometriosis patients, as estrogen encourages endometriosis growth. Low estrogen / high progestin pills may control the growth of endometriosis when it is not severe.
Many patients are asked to take the pill continuously—skipping menstruation altogether.
My BCP Rollercoaster
I think I tried at least 15 different birth control pills over a six-year period in an attempt to control extreme bleeding and pain before other medications were considered.
None stopped the pain or the bleeding. And in fact, I bled for two years straight, without a break, despite taking these pills!
By spending so much time on 'just trying another one', and not following other diagnostic channels (ultrasound, MRI, laparoscopy), my endometriosis was allowed to grow to extreme levels.
Finding a pill that works best to balance out hormone levels, however, is not easy, with many patients jumping between different brands.
Blood tests that show hormone levels can help with the appropriate choice, but most doctors (in my experience) don't prescribe these tests.
Some patients do well. Others may develop (mild) side effects: acne, weight gain, nausea, migraines, and high blood pressure are some of the more common ones.
Common Birth Control Pill Alternatives:
- A skin patch applied once a week for three weeks, then a week break for menstruation.
- Vaginal ring, left in place for three weeks, then removed for menstruation.
Treating Mild-to-Moderate Endometriosis
Progestin-Only Pills, Injections, and Implants to Mimic Pregnancy
Avoiding estrogen in medications often works better for endometriosis patients. Endo is an estrogen-dependent disease—too much estrogen allows the endo lesions to grow.
My Current Endo Medications
After six operations, three courses of the strong medications in the next section, plus nine years of the Mirena IUD, there are still endometriosis cells in my pelvis, as shown from the most recent biopsies taken during my hysterectomy.
Visanne (in addition to the Mirena) managed to stop my periods, despite a number of side effects. But it hasn't stopped the bowel bleeding.
After a short break to recover from the operation, I'm back on Visanne, and will be until I reach natural menopause.
Progestin (synthetic progestogen) tricks the body into believing it is pregnant, stopping ovulation and menstruation.
Daily progestin-only pills are helpful in alleviating endometriosis symptoms, often more so than estrogen/progestin combination pills.[2,4]
The most recent progestin-only pill, Visanne, uses a different type of progestin. Visanne is the first medication to specifically target endometriosis and is slowly being approved around the world. However, this is not a birth control pill; other contraceptive measures should also be taken.
- A three-month injection (such as Depo-provera), was shown to be just as useful as progestin-only daily pills in reducing endometriosis symptoms but has increased side effects.[2,5]
- A three-year implant (such as Implanon) can be injected under the skin in the upper arm and slowly releases progestin into the body. It also has increased side effects.
Although breakthrough bleeding and spotting are common, many endometriosis patients are happy with how it controls symptoms.[2,3]
- The five-year slow-release Mirena IUD deposits progestin directly into the uterus over time. This method is recommended for women who have adenomyosis, as it lessens bleeding significantly.[2,4,5]
I'd recommend that insertion is done under anaesthetic—my first was done 'in the chair' with no anaesthetic, and it was the most painful thing in my entire life!
The longer-term medications are certainly easier than remembering to take a daily pill and may be effective for light to moderate cases of endometriosis, as the body is tricked into not ovulating and avoids menstruation.
Treating Severe Endometriosis
Severe endometriosis is usually treated with a combination of the medications below and the surgical removal of endometrial lesions and cysts via laparoscopy.
There are some extremely strong medications tricking your body into producing menopause-levels of estrogen. Of course, you get all the menopause symptoms—hot flushes, vaginal dryness, mood swings, memory problems, etc.
1. Gonadatrophin-releasing hormone agonists (GnRH-a) have a lot of additional side effects, some severe. They suppress the pituitary gland to reduce estrogen production.
Zoladex (goserelin acetate) was originally developed to treat prostate and breast cancer, but has been useful in reducing endometriosis and adenomyosis growths. It is also used when the blood supply to endometrial lesions prevents safe removal in operations.
A Hellish Medication
Zoladex is an awful medication. It felt like it was beating my body and its systems up as if it was a pro-boxer.
A three-month treatment in between operations two and three and another six-month course after operation #5, left me never wanting another course, even if I was allowed!
The full spectrum of menopause symptoms, plus extreme nausea, dizziness, memory problems, non-functioning immune system, and more, were not helped, even with the add-back dose of estrogen.
But, it allowed the endometriosis to be removed in surgery and did shrink the adenomoyomas in the second course.
Unfortunately, the endometriosis lesions started growing in my bowel around two years after my second Zoladex treatment, and the adenomyomas are starting to regrow.
As it can substantially decrease bone density and increases the risk of osteoporosis, a maximum treatment of two six-month courses is recommended in a lifetime. Although for difficult cases, this is often extended.
It is injected monthly, as a slow-release implant, into the fatty tissue of the stomach.
In cases where menopause symptoms are too severe, additional estrogen tablets may be recommended. Whether this affects the performance of the goserelin acetate, is unclear.
Other GnRH-a Medications
- Lupron - three-month injection into a muscle (typically stomach)
- Synarel - twice-daily nasal spray.
- Elagolix - tablets or capsules twice a day, currently undergoing clinical trials in the US.
2. Danozol uses testosterone to reduce estrogen production to menopause levels, and is occasionally recommended when treating difficult endometriosis cases.
However, it has a large number of serious side effects and is not well tolerated, therefore Danozol is not often recommended.
Which Medications Have You Taken to Treat Endometriosis?
How did they work for you? Side effects?
Did they reduce or get rid of your endometriosis?
Please share your stories in the comments below!
- Estrogen metabolism and action in endometriosis, Rizner TL, Mollecular and Cellular Endocrinology, 2009 Aug 13;307(1-2):8-18
- Modern combined oral contraceptives for pain associated with endometriosis. Davis L, et.al., Cochrane Database Syst Rev. 2007 Jul 18;(3):CD001019.
- The effects of implanon in the symptomatic treatment of endometriosis, Ponpuckdee J, Taneepanichskul S, Journal of the Med. Assoc. of Thailand, 2005 Oct;88 Suppl 2:S7-10.
- Progestagens and anti-progestagens for pain associated with endometriosis, Brown J, et.al., Cochrane Database Syst.Rev. 2012 Mar 14;3:CD002122
- Levonorgestrel-releasing intrauterine system (Mirena) and Depot medroxyprogesterone acetate (Depoprovera) as long-term maintenance therapy for patients with moderate and severe endometriosis: a randomised controlled trial, Wong AY, et.al., Aus & NZ Journal of Obstetrics & Gynaecology, 2010 Jun;50(3):273-9
- Endometriosis, Fritz MA, Speroff L, Clinical Gynecologic Endocrinology & Infertility, 2011:8, 1221-1248. (GnRH-a success)
- A wonderfully informative and supportive website is Endometriosis.org. They also have information about Endometriosis Awareness Month, held annually in March, during which many events and conferences are held worldwide.
This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.
Kymberly Fergusson (author) from Germany on November 02, 2012:
Teresa - The doctors are still trying to put off that option for me -- I'm too young (they found mine at age 24). I suspect if this doubling of Mirena and Visanne doesn't work, they might suggest a hyster. I'm so glad your sister has been symptom free since her op.
Denise - The 'official' numbers are 1 in 10, but I suspect it would be much higher. There are many women who have endometriosis without pain! Thanks so much for sharing!
Denise Handlon from North Carolina on October 30, 2012:
Very interesting article and well presented with the information, as well as the table, polls, and photos. I am surprised that the stats indicate only 1:10 I would have guessed it would be more like 1:5. Thanks for sharing. Rated up/U/I and sharing.
Teresa Coppens from Ontario, Canada on October 30, 2012:
Very useful article. My sister had this awful disease and was given the option of a complete hysterectomy. Although she does take some hormonal replacement drugs she has been symptom free otherwise. It was a tough choice as she was still in her childbearing years. I hope you find some relief Kymberly in your new medication.