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Prozac: Finally, Something That Works for My MS Fatigue

I've been living with MS for 25+ years and have tried almost every medication available. I have also been evaluated and tested extensively.

Here are my thoughts on Prozac, which I was prescribed for severe MS-related fatigue.

Here are my thoughts on Prozac, which I was prescribed for severe MS-related fatigue.

My Experience

At long last, I have a success to report! Finally, a drug that helps me with my fatigue. I never thought I'd be so happy to tell the world I am a Prozac user, but I truly am excited and thrilled to report it appears to be the right match for the fatigue that has plagued me for at least 11 of the 16 years I have been living with MS.

As excited as I am about this miracle drug, I would be remiss if I didn't tell of the side effects and the length of time I was out of commission.

At a dosage of 20 mg, I suffered from side effects for three days that consisted of:

  • dizziness
  • nausea
  • irritability
  • slight scratchiness in my throat

After three days, all the side effects were gone. I like it when side effects clear up gradually because it means that every day, you feel better, not worse. This time, I did not have any sort of breakouts or itching. I think the fact that it is an older drug might have something to do with it. I have trouble with anything my doctors tell me is a "new" drug because they seem to make me itch or break out in hives. No such trouble this time around, however.

I've Tried Many Drugs and Supplements, All of Which Have Failed

I will attempt to recall the list of drugs that failed me, just as a point of reference for anyone who now finds themselves in a similar situation to mine—no drug seems to work!

I hope that you have friends who will encourage you to keep looking, even when you feel it is hopeless. Thanks to my friends, some from right here on HubPages, my hope was renewed, and my enthusiasm rekindled.

Drugs that haven't worked for me or had a limited effect include:

  1. Provigil
  2. Nuvigil
  3. Amantadine
  4. Zoloft
  5. Paxil

Cylert can't really be added to the above list because I did feel better using that drug, but for safety issues, it was discontinued. It did work for me, though, and I didn't personally suffer any ill effects.

I Even Tried the Herbs and Vitamins Route

Over the years, I have also gone down the herbal route with limited to no success. It was very frustrating as the herbs I tried helped so many others around me, yet for me, there was little to no benefit.

Recently, I had hoped Vitamin D3 would be the key to unlocking the energy hidden behind the MS. It worked, but only for two days. It was crushing to get my hopes up high, to feel excitement over finally finding "the answer," only to realize it was just a two-day-long cure.

Ritalin and Adderal

These are two last-hope drugs I am hoping I will not have to try: Adderal and Ritalin.

Secretly, I like knowing I have at least two more chances if Prozac fails. As my list of ineffective drugs grows, it is nice to feel that there is a backup drug category to fall back on.

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What I know about these drugs could fill a thimble, I suppose.

I know they are in a different category of drugs. That they are highly monitored. That they are being abused by many people, including teenagers, as a means to get high.

The most ironic piece of knowledge that I have, however, is that both drugs are used as a calming influence for hyperactivity. Why this drug works off-label for MS fatigue is something I don't even pretend to understand. But they are available, and I have put them in my fatigue arsenal, just in case.

Fact Sheets on Adderal and Ritalin

When Your Neurologist Is Not Enough Help

Overall, I am generally very pleased with my neurologist. He is a gentle caring man who worries when I don't take the necessary steps to keep MS progression to a minimum.

However, I was very disappointed once I realized my latest drug, Nuvigil, would not be any help. I assumed he would try a drug I really wanted to test drive, Ritalin. But it was a no go from the time I called his office to the time his nurse talked to me for the second time. Although I have first-hand knowledge of others with MS who were helped to function by means of Ritalin, he was unfazed, and his stance that he did not like Ritalin never changed.

So . . . when your neurologist is not giving you enough help, don't forget your primary doctor can still come through for you. I have had the same doctor for 14 years now. He has seen me at my best and when I have literally dragged myself to his office because the fatigue was so bad.

Talking to him was a big help. He explained why he couldn't prescribe Ritalin to me. Insurance carriers don't like it when a doctor goes off-label, especially with a drug like Ritalin that is highly monitored.

He told me a neurologist could prescribe it and that, if need be, he would give me a name if he couldn't find another drug to help me.

Having been listened to and understood was quite calming. I was willing to try his suggestion.

How reassuring it is to know that his suggestion is the right one for me.

My Prozac Strategy for the Upcoming Months

Presently, I am enjoying my ONE hour of energy. It is amazing what you can get done. Just ask yourself, "If I only had one hour to perform any physical activity, apart from secular work, what would I do?"

No doubt you would do as I have done: look for what screams the loudest for your attention and get to that item/items first.

How would you feel about the rest of the jobs you didn't get to? You could feel frustrated, angry, disgusted, or depressed . . . or you could feel the way that I feel, which is: "It will be there waiting for me the next time I have an hour's worth of energy." I find that to be the most positive viewpoint to keep.

I may not finish as much as I want, but at least I can finally get a running start at it all. It makes me very happy to be able to say that, finally!

Upping the Dosage

As my doctor explained. Prozac is an "old" drug and has been around for a long time. I can increase the dosage from the 20 mg I currently take to 90 mg if need be. Of course, I hope the need will NOT be that strong. Thus far, I feel the Prozac leaves my system by 4:00 pm. I take it around 8:30 am. So, I am thinking another pill should provide me with what I need and eliminate the crash that occurs once the drug has had time to move through my system.

I have been told to wait four weeks between each increase, so I still have a good week to go before I increase the dosage. And if it turns out that this one dose lasts longer than eight hours, so be it. I will be happy to keep the dosage where it is.

Final Thoughts

Prozac seems to be the drug I have been looking for all these many years. If it stops working, I'm glad I still have a few more options to try. I hope everyone suffering from severe MS fatigue finds the drug that works for them. As my doctor told me, "it is different for everybody." That difference is what can become so discouraging. Finding the one drug that works is worth all the effort, however. So don't give up. Surround yourself with friends and family who won't let you give up. They can really help you if you get discouraged trying to find the right drug for you.

Update: As of 2018, I moved on to Adderal for fatigue management. While Prozac served its purpose, its success was for a limited amount of time. I use Adderal very sparingly, and my current neurologist highly recommends its use while leaving the frequency of its use to my discretion.

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.


Emma from UK on June 22, 2012:

I am on Prozac for depression, my depression is managed with Prozac but I get serious fatigue with it. Other than the sleepiness I am happy with Prozac, it works for me.

I hope Prozac is still working for you this far down the line.

Darline Kilpatrick (author) from Delaware on November 23, 2011:

Thank you both for your comments and concern for my well-being. I believe both comments are sincere and have my best interest in mind. :)

steph on November 18, 2011:

Hi Jen! I'm glad you are feeling good with Prozac,however, because of what I've leared at work...the right thing for me to do is share a little bit of information. Google: the aftermath of Prozac by Ann Blake. I don't want to be negative, but there has to be a better way, the side effects of Prozac are proven and dangerous. Please be careful, Hope this information will help you make a better decision.

Myke on April 06, 2011:

Yoy had´not MS/CFS but hidden depression, that´s the reason why Prozac helped you!

Darline Kilpatrick (author) from Delaware on January 23, 2010:

Please let me know if Prozac ends up helping your friend, fishtiger58. I can't imagine being in so much pain and having to deal with extreme fatigue at the same time.

fishtiger58 from Momence, Illinois on January 23, 2010:

I have a friend with severe Fibro, I wonder if Prozac will help her. I will suggest it to her. Fatigue is a big issue with her Fibro. Thanks for a great read and hang in there.

Darline Kilpatrick (author) from Delaware on December 12, 2009:

Thanks poetlorraine, after 16 years of living with it, positives mean a lot. ;-)

poetlorraine on December 12, 2009:

i feel sad that you have this condition, but you are looking at the positives, and that is always a great sign

Darline Kilpatrick (author) from Delaware on December 12, 2009:

Thanks xunlei

xunlei on December 11, 2009:


I'll keep your post

Darline Kilpatrick (author) from Delaware on December 11, 2009:

Hi Paradise7, I look forward to reporting continued good news. Thank you very much for your sincere well wishes. It means a lot to me. :-)

Paradise7 from Upstate New York on December 11, 2009:

I am so glad that, as of now, the Prozac is working. I have been following your valiant struggle with more and more admiration every time I visit your hubs. Best of luck and wellness to you, dear Jen--all the best over the holiday season.

Darline Kilpatrick (author) from Delaware on December 10, 2009:

Ethel, my comments keep vanishing too. I posted a comment to you hours ago and it has vanished! Again, I thank you for re-posting your comment. And for your good wishes in my behalf. I too look forward to Prozac continuing to do the trick. Thanks my friend!

Ethel Smith from Kingston-Upon-Hull on December 10, 2009:

I will try again as my comment vanished. I hope Prozac keeps working for you. Your hubs are essential reading as they tell it how it is and from a patient's perspective.

Darline Kilpatrick (author) from Delaware on December 09, 2009:

Wow my reply never made it, so once again with feeling . .

Hi Val! I am glad you have good things to say about Prozac. I hope you are able to get back on it soon, there is nothing quite as bad as being depressed AND fatigued from MS. I look forward to hearing that you are feeling better soon. Did you notice that Prozac suppressed your appetite? I think it has suppressed mine, which is NEVER a bad thing! lol

Connie, I love the fact that you are my constant encourager. You really helped me when I was down and wanted to stop hoping for a "find", thank you for your support. I actually waited before I posted about Prozac. Soon it will be 4 weeks. I think I'm good with this one, therefore. :) I will decide about the increase in dosage when the 4 weeks arrives in full. But this is so great! I'm so relieved there is a pill out there with my name on it. LOL

Thank you both for leaving your comments. As always I appreciate them.

Connie Smith from Tampa Bay, Florida on December 09, 2009:

Jen! I am so happy that you've found something that is working. You didn't say how long you've been on this one, but it was loud and clear that you aren't getting your hopes up too high in case it might quit working after continued use. Keep the faith, girl. As you say, there are more to try, but this one is working! I pray that the search is over and this is the one for you on a long term basis.

Violet Valerie from Westminster, Colorado on December 09, 2009:

Glad you had success! I took Prozac for years for clinical depression and always appreciated the fact that it gave me energy in addition to making me feel happier. I am actually hoping to go back on it in the near future both for the depression and in hopes that it would help with the MS fatigue, glad to hear that was a good thought!

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