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My Journey Combatting Skin Cancer With Efudix

After researching treatments for solar keratoses, I decided to try Efudix. I want to share my experience with others considering treatment.

This is me and my five-year-old son, Ryan, before the treatment.

This is me and my five-year-old son, Ryan, before the treatment.

How It All Started

I grew up in a very normal Queensland family—plenty of time spent in the sun, yet always aware of the dangers of sun damage. I had red hair and plenty of freckles, which should have signaled me to always slip-slop-slap on some sunblock.

Now, at 31, I am well aware of the ramifications of our 'it'll be alright' attitude.

I am fortunate enough to have family and friends that constantly remind me to have my skin checked. At the age of 25, I had a very small basal cell carcinoma removed. At the age of 31, my dermatologist told me that there were many more signs of sun damage on my face and hands and that I would be in a world of pain if I waited to treat them.

As you can see from the above picture, I had no reason to think I was in danger or that I would need to undergo any treatment that would involve topical chemotherapy. Little did I know!

After spending months considering the Efudix topical treatment, getting second opinions, spending hours researching on the internet, speaking with a natural therapist, and speaking with others who were treated, I decided to take the plunge. Not only did I hope my solar keratoses (skin spots) would be gone in a month, but I hoped for much younger-looking skin.

The following is my day-to-day account of my treatment.

Day 1: 5th September 2010

Today is day one. I have the cream and have prepared the family for what the next month will entail, which is especially hard to do given the unknowns. Once dinner is done, I will be applying the first round of Efudix. I am apprehensive and have concerns about the burning and itching starting right away. I am also a little excited that I am one day closer to the treatment being completed and a more youthful me.

After the first application, my only concern is whether I have used enough.

After two hours: There is some very slight tingling, but I am wondering if this is simply a result of me focusing on how my face is feeling.

Day 3: Just a little shine. So far it's only tingling.

Day 3: Just a little shine. So far it's only tingling.

Day 4: Now I Can Feel It

Day four has started in a fairly uninteresting manner—out of bed, into the shower, wash my face with just water (is that really washing?), then reapply at 6:30 am.

At this point, I am thinking that the first week is going to be a breeze.

It is now 12:30 pm, and I am just starting to feel some real effects. My face is feeling quite warm—like I have spent too much time in the sun. The itching is getting a little more consistent, and my face is starting to get red and blotchy.

Day 6

Day 6

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Day 6: So Far, So Good!

Well, I have almost made it through the first week, and so far, so good.

There have been a few moments during the course of the day when the consistent itch became a real irritation, and there have also been times when I would liken the warmth on my face to a hot flash. So far, keeping busy and keeping my mind occupied seems to be helping.

I am applying the cream right after a shower twice a day and am starting to find the cream is taking much longer to soak into my skin. Last night, I waited about 20 minutes after my shower to let my skin dry out before applying the cream, and I noticed that the application of the cream was a little gritty.

Having my face directly under the hot water in the shower is creating some discomfort, so now I have to just splash my face. No real issue.

I am also treating the skin on the back of my hands, and I can honestly say that I have not felt any pain or had any discolouration there yet.

You will see from the photo that the colour of my skin is not yet a real problem, though I have had some comments today about spending too much time in the sun. I think I am only days away from being particularly unsightly.

 Day 10

Day 10

Day 12

Day 12

Day 12: It Is Becoming Challenging

It has been six days since my last update, and up until today, I had very little new experience to share. It was just more of the same—hot flashes, tightness in my skin and a slight headache.

Today was a different story.

I woke up this morning with a headache and a lot more stinging pain on my face. My morning routine since day eight has been simply a shower in a can and a quick splash of water on my face to get rid of any residue left from the night before. This prepares my skin for the next application. The direct water on my face is no longer bearable, and the steam in the shower is also causing some discomfort.

Between towel drying (very gently patting) my face and applying the next dose, my stinging skin brought some tears to my eyes, but I keep telling myself that it is fine, we are almost halfway through the treatment—stay tough. Then, as I apply the cream onto my dry skin, the grit and the scratching only add to the pain.

All the while, hubby and my five-year-old are in bed keeping a close watch, making sure I am okay. What can I say? I am fine and just need a few quiet minutes to let my fiery skin settle down. After some quiet, and coffee and toast, we are back to where we were yesterday—just feeling generally uncomfortable and hot and scratchy.

Funny story: Last night after dinner, I noticed in the mirror that I had what looked like the remnants of a beautiful dinner on the edge of my mouth—which my hubby and I thought was pretty funny. Now that it hurts to stretch my mouth too widely during dinner (or if I laugh or smile too hard), it was quite possible that there was food on my face. But no! Closer inspection revealed parts of my skin flaking and clumping at the corner of my mouth—which is particularly unsightly.

So I will continue on with my day—headache in the background—not laughing too hard and continually keeping my mind busy to avoid the discomfort of my face.

I would love to hear from anyone else that has been through this treatment.

Day 14: It is really hard to smile for a pic.

Day 14: It is really hard to smile for a pic.

Day 14: This Is No Fun

It is hard to remain positive when you are running on limited sleep. Last night, after bedding down early (after an uncomfortable day in the office), I woke up at about 11:30 pm because my face was aching terribly, and the all-over itching was unbearable. After two Nurofen (ibuprofen) and two hours of reading (to take my mind off the itch), I finally got back to sleep, although the rest of the night was quite restless.

This morning, I took my time dragging myself out of bed, then went through the morning ritual—shower in a can, a splash of water on my face and then more Efudix. It took a good 30 minutes for my face to calm down, even after more Nurofen. The headaches were not a problem today. The main issue was the constant aching and the stinging, dry feeling I am battling. There is a constant sense of pressure on my skin that makes me feel that if I smile too big, my face will literally crack.

Both eating and speaking are much more difficult. My family and I are selecting our meals more carefully, eating only things that can be cut into small pieces.

I am meeting with my doctor on Monday (day 16), and I am hoping he will tell me that I am through the worst of it, but I think this is wishful thinking.

Thanks so much to my family. I really am so grateful for your love and support.

Day 15: Call the Doctor

What a day! After a restless night's sleep, I woke up in pain. The burning, aching, and itching feeling is constant and extreme. I had a home call from my doctor at midday and was given Panadeine Forte (acetaminophen and codeine) for the pain. The remainder of the day was quite bearable.

I am not going to be shy with pain relief—there's no point in making this experience any worse than it needs to be.

Day 16: How much worse can it get??

Day 16: How much worse can it get??

Day 16: Efudix Follow-Up With the Dermatologist

What a day, and what a difference a few hours can make!!!

I slept a little better last night—the Panadeine Forte is doing its job.

What a sight (see the above pic). It seems that overnight more of my face has scabbed over, and the dryness on my face is much worse than what it has been up until now. BUT, today I have a good reason to soldier on. I am meeting with my dermatologist to review my Efudix treatment, and there is a little part of me that is hoping that he will say we have done enough and that I can stop applying the cream and begin the recovery phase.

Two more Panadeine and hubby is driving me to the doctor. I am feeling extremely self-conscious because I am looking like a real sight. This is the first time my hubby has been out with me since I started treatment, and he is a little amused at the awkwardness he sees in the reaction of the people we pass. I have a slight (very slight) understanding now of how disabled or disfigured people feel when they are in public.

The first thing the doctor says is, 'Oh, you have had a fairly extreme reaction, it must be sore'! He then continues to tell me that while my reaction is extreme, it is a good outcome because we have gone deep enough—removed enough layers of skin—so we can STOP applying the Efudix! I am not sure whether to laugh or cry (mind you, I am still pretty dopey from the pain medication). Oddly enough, I am apprehensive to stop and question his reasoning—I really need to be sure that we got it all. I don't ever want to have to go through this again. The doctor assures me that it is time to stop with the Efudix, and it's time to start putting moisture back into my skin and allowing the new skin to come through. It may take another couple weeks before we see any great results, but this a huge step forward.

Funny thing, my hands (which I have also been treating for two weeks) are still showing very little reaction to the treatment, so we will continue to apply the Efudix for another two weeks, at which time I will be meeting with my doctor again.

After coming out of the doctor's office, all I can do is cry. I cannot believe that this is almost over.

Day 16, Part 2: Recovery Begins

So in stage two, we begin putting moisture back into my skin and allowing my body to do its job and start the repairing process. I have a prescription for some steroid-based cream to reduce the swelling, the redness and the pain. This cream can only be applied once a day. I have also been told to get a very heavy, greasy moisturiser to keep my exposed skin covered while it heals. I can not wait to put some moisture back into my skin!

Fortunately, my sister is available to do a quick trek to the health food store to get me the best available creams to do the job. Within an hour, she arrives at my doorstep with some manuka honey moisturiser and some shea butter. This combination should soothe, heal and protect my skin.

After just the first application of moisturiser, I am feeling like a new woman. I can open my mouth without excruciating pain, I can rub my lips together, I can speak normally and I can smile. I will continue to apply these creams as my face gets dry and will use the steroid cream if absolutely necessary.

As I look back over my day, I have mixed emotions. Looking at this morning's photo brings tears to my eyes. Now when I look in the mirror, my face is red and shiny. It's still a little itchy and sore, but it is SO much better.

Day 18: Recovery Day 2

Day 18: Recovery Day 2

Day 18: Recovery Day 2

Today is my second full day of the recovery phase, and I was thinking that things should start to improve. Unfortunately, that hasn't really been the case. The pain continues, and the itching is worse, but the upside is that I am now able to smile, smirk and speak without the fear of splitting my face open.

I am still taking the Panadeine at night because I need a good night's sleep to get me through the day. When I wake up in the morning, I feel nauseous, and I still have a headache. After breakfast in bed (thanks to my boys), I slowly make my way into the day with my new routine. I take a quick shower to splash the remnants of last night's moisturiser off my face, pat my face dry with a tissue and reapply the moisturiser. Then I am ready for the day.

The creams I am using are keeping my face moist until about midday. Around then, parts of my face start to dry out, while other spots are very moist, and the skin oozes a clear liquid (which has an interesting odor). I understand that this is normal. When my face gets dry and air comes in contact with the bare skin, it's painful. So I have to have a quick pat down, then reapply the creams. For the remainder of the afternoon, the itch and stinging are unbearable. It is a good excuse to take an early mark from the office and get home to shower and repeat the moisturiser application process.

After two and a half weeks, this process is just getting me down. I cannot wait to get my life back. I hope it won't be much longer.

Day 19: Recovery Day 3

Day 19: Recovery Day 3

Day 20: Recovery Day 4

Day 20: Recovery Day 4

Day 20: Recovery Day 4

Not a lot of new experiences or information to share. More of the same—headaches, nausea in the morning, and all-day stinging and burning with patches of dryness. I am reducing the amount of painkillers I am taking, and fortunately, I am still getting a good night's sleep.

Earlier this week, I spoke with a friend who has done this treatment before, and we spoke about the oozing and the goop, and the smell that is particularly unsavoury. He described this smell as 'the smell of death', and I think he is spot on.

I am really quite tired of this ordeal, and I think I am becoming a lot less tolerant. I am usually considered a pretty tough person, but now I'm really questioning this. How do other people that go through this treatment cope?

I am going into another weekend that will be spent entirely at home. Exposing my face in public right now is uncomfortable and not my favorite thing to do.

I have attached pics from yesterday and today, and I hope that the next time I upload a picture, it will look very different. I am confident that by the end of the weekend, the worst of it will be over. We'll see!!!

Day 24: Recovery Day 8

Day 24: Recovery Day 8

Day 24: Recovery Day 8

It is amazing the difference a few days and a tub of moisturiser will make.

The past few days have been pretty uneventful. The pain in my face has dramatically reduced and is really just a discomfort that comes when my face starts to get a little dry. The mornings are still tough after my face has gone hours without moisturiser. As I reflect on the past two weeks, I feel that I am in no position to complain; what I am dealing with right now doesn't even compare to what I was experiencing before.

Today's photo was taken this morning, and now five hours later, I am seeing further improvements. I think I am getting some glimpses of what my new skin will look like. As the layers of dryness are removed, new skin that is smooth to the touch is revealed. So far, it looks flawless. I can only hope that this is how my whole face will look in a few short weeks.

I am still applying Efudix to the backs of my hands but have reduced the application to just the spots I can see. I am now, after three weeks, feeling some tenderness in these spots, but after the ordeal I have been through with my face in the past few weeks, I think I am pretty well prepared to see this through.

Just today, I have a spring back in my step and am confident that I will be able to show my face in public again in just a few days.

Day 25: Recovery Day 9 – continual improvement

Day 25: Recovery Day 9 – continual improvement

Day 26: Recovery Day 10 – I'm surprised by the improvement!

Day 26: Recovery Day 10 – I'm surprised by the improvement!

Day 28: Recovery Day 12 – I feel great! Just a slight itch all over my face and some tenderness when I touch my cheeks.

Day 28: Recovery Day 12 – I feel great! Just a slight itch all over my face and some tenderness when I touch my cheeks.

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.


KathGH on May 23, 2019:

Hi there

I am about to embark on the Efudix torture over my entire face like you did :-)

I read through your article.

What I want to ask you is - besides removing the sun cancer spots, did you get a more youthful skin that you hoped for as the other benefit? That is definitely a motivation for me as I have pigmentation too which I cant remove with the hydrogen ice burns...

I don't see any photos of you once you are completely healed.

Thanks so much

Kind regards

Kath, South Africa!

Clifton Donnelly from Brisbane on December 29, 2017:

Many thanks for your most interesting description of your efudix treatment.

This is very informative & educational in what I might expect as I start treatment this week.(Dec2017)

The two or three photos my Dr showed me hardly covered the extreme results.

I am now so much better prepared to (lol)face the treatment and side effects, Thanks to your blog.

Well done!





P.S. Everyone else starting treatment, I'd highly recommend reading thru ALL the comments below...

Many good tips & lots of slightly differing experiences to be learned!


Johann on June 15, 2016:

Hi there, I have been advised by my dermatologist to apply Efudix twice daily for 2 weeks. I am on day 5 and my skin is starting to feel tender to the touch and somewhat stiff. Not looking forward for what is still to come though . . .

goospanish on October 30, 2015:

Some do. cancercompass has a lot of information. I'm on day 2 of treatment

Maggie on October 24, 2015:

I used Efudix on my face, both cheeks and chin all areas. At day 15 of daily application, my reaction was so severe that my consultant said stop (my GP had prescribed it for 4 weeks use). I am into day 3 of recovery and my face is covered in dried up puss-y scabs. Just hope I don't get any permanent scarring. Any others get this?

Joan on November 09, 2014:

I'm on day 31 with a spot which is getting larger due to the treatment. No headaches but the pain is increasing along with the itch. My forehead is very unsightly and strangers ask me what happened. I just tell them it is skin cancer and that I'm okay.

Donna on September 21, 2014:

I was so glad to find your article. I felt I was on my own doing this treatment. In a strange way it is rather comforting that so many others have gone through and are going through what I am now. You can feel quite alone and isolated. I am Day 18 and just reading your article and seeing what you have gone through makes me feel better. You were brave to post your journey but it certainly has helped mine. I have not experienced the amount of discomfort you did. Thanks again :)

Fiona on August 20, 2014:

Great to read your experience kirsty, im day12 and its good to see that what im going threw is normal, not very nice but the end result better be worth it

Frank on May 23, 2014:

another ex-Qld'er here - (highest skin cancer rate in the world - a lot of white people with an outdoor lifestyle in a sub/tropical sun - d'oh!) - I got my first BCC at 31, and have lost count of how many I've had frozen off or cut out - now 60 and with regular 6 monthly checkups (last week found a small BCC on my back - doc said 'make a 30min appt to cut it out - no hurry - these are slow growing), I've only just been told about efudix/fluorouracil by my partner (that her boss is using it on his forehead for a superficial area) so am reading about this for the first time.

My father was a doctor, I did a year of medicine so can scan such info quickly - metabolic inhibitor, targets fast growing cells, recommended for superficial pre-cancerous spots where usual removal methods are not suitable (I'm guessing eye lids or large areas on the face that have been left untreated for too long).

I'm a bit confused - read this story of nearly dying from anaphylactic shock from using too much of this stuff - - it almost looks like the same story.

My thoughts from 30 years of having skin cancers removed and my doctor's suggestions - if it's a real BCC better to cut it out - they can then biopsy it to check they've removed all of it - simply freezing/burning off the top layer can come back and bite you if it spreads further underneath while the top layer is 'healing'

if it's pre-cancerous/solar keratosis only - then maybe - but maybe don't use too much unless you're ready for a world of pain and can lock yourself away from visibility for a fortnight.

and of course if it's a rapidly growing spot - look out for dark/irregular/multi-colour/red or purple/raised/crusty spots - get it checked by a skin doctor - in Qld they should know - not like Taiwan where I went to the skin 'specialist' with a BCC - he looked at it (hadn't seen many I guess) told me it wasn't a BCC - OK - I came back to Oz, went to my skin doctor, he said yes it is and removed it. So don't trust everyone you hear - get a second opinion - it's your life - humans make mistakes all the time - keep looking until you find your answer !

Sharon S on March 20, 2014:

Omg - I've just completed Day 4, and I'm freaking out. The doctor gave me the script, $69.00 later, and it's only now I've wondered what I was getting myself into. I'm going to continue, but I had absolutely no idea what I was I do, and I'm crapping myself ahhhhhhh

Tom on January 03, 2014:

Hi Kirsty

Thanks heaps for sharing your experience, Ive just completed 21 days of treatment and my face feels and looks like the top of a pie with sauce, red, crusty and flaky. I'm off to get some manuka honey moisturiser and shea butter. I wasn't sure if it was ok to use anything after the treatment.

thanks again

Pat on December 29, 2013:

Why didn't you just use Black Salve in stages?

sara on December 11, 2013:

I'm also using efudix on my 3rd WK ,I had a biopsy which showed solar karatosis... I apply twice a day but unsure if I've been applying to a wide enough area of skin...? Just put cream round biopsy site..! Should I be doing the whole left cheek..? Kirsty your so strong as I know its very painful..!! X

jo on October 15, 2013:

i am in week two of the cream and it is really sore woken up in the night with my face stuck to the pillow case ,i cannot wait utill they journey is over .done with this .it is so sore

julie on September 24, 2013:

For a scaley nose that had been iced off twice my specialist recommended efeudix.. I found this type of treatment was absolutely cruel . It feels like your face is exploding, think about rice bubbles, snap crackle and pop,.. that is what your face feels like. There has to be a more humane way to combat skin problems than this. Its been 6 months and having my face peeling away and most nights crying and bleeding let alone no sleep because of the pain , My face cries for continual moisture. I need to moisturise at least 3 times a day with a heavy based moisturiser. These specialist need to go back to school and find another way , and you know what , I didn't have skin cancer . , I had a sun spot, I found out after, and went through all of that.

Monique on September 13, 2013:

Hi Kristie, I contacted you a year ago and I'm only now finally doing the Edudix treatment. I also just had PDT on my nose (very painful!) I've got 5wks off from work. On my 4th day and still no redness yet -just want it to hurry up and start so the sooner it will be over with! It would be great to know how your face is now 2 yrs later. Have any more skin cancers appeared since your treatment? It's not fair - our skin is just not cut out for the harsh Queensland sun :-(

Andy on January 22, 2013:

Hope you are well now , I have been perscribed Efudix for a mark on my forehead . Your post has been very informative , It's such a shame that something as natural as the sun can do us so much harm . I also have to use it on my shoulder , so I think I will try it there first .

Nicky on November 19, 2012:

I Kirstie and all readers from this blog. Once again from the island Bonaire. I stopped using Efudix a week ago. The first 2 days of recovery I used olive oil for the pain and dryness. The third day up till now I used aloe vera fresh from our garden. Take of the peel and just rubbed the slimy jelloish inside on my face. Now afther one week all the dead skin is vanished and I am looking and feeling great. Regards Nicky

Nicky on November 04, 2012:

Hi Kristie, I'm very glad you were so brave to make this blog. It is a great help for me. I started 8 days ago, still have about three more weeks to go. Up till now i only felt a bit nausea and skin is getting dry. I'm taking pictures every 3th day, so I can make a photo collage for the dermatologist. I live on Bonaire a small island un the Caribbean, information is not so good over here. Thanx again!

Heather on September 17, 2012:

Hi Kirstie,

I've just stopped using Efudix after one week of treatment on my face. Doc advised this morning that the treatment had already done its work. I've read so many different opinions about post-treatment creams that I am confused as to what is best. My doc has prescribed 1% cortisone ointment with a vitamin e healing moisturiser. I'm also mixing all this with a little anti-bacterial cream to stop the possibility of infection. What healing creams did you use? I also grew up in Qld.

ZackfmLondon on July 10, 2012:

Congratulations on your courage.

Its now probably 6-9 months since recovery.

Can u tell us how your face looks in comparison to the pre-treatment?

Appreciate if you"ll add a recent pic.



jason from brisbane on May 29, 2012:

I have just started my efudix treatment and was not told by my doc how to apply or how long 4 tho reading ur story now i no how to use the efudix .I will use it for 4 weeks and see how it ends .Thanks for the positive comments from you guys

jason .

Denise on May 26, 2012:

I am on day one of recovery and the pain is still evident. I have not hidden myself away but feel very self-conscious at work and going out in public. I was told by my dermatologist to apply twice a day for three weeks but only Monday to Friday. Thank you for sharing with photos. I have only one photo taken at the end of treatment. Just to remind myself what I have had to endure. Let the healing begin.

Linda - Aintree Village on May 15, 2012:

I'm on day 19 of 21 using Efudix on my chest - was ready to give up as pain and scratching is so unbearable until I read this - haven't been off work so far but don't think I can continue as I work in High School. Your story has made me grateful it's only on my chest - thanks for the useful information and inspiration to carry on.x x x

Peter on April 25, 2012:

Thank for sharing your experience for the benefit of those of us who are starting the journey. Your courage has inspired and helped me enormously.

Chandrika on April 17, 2012:

Well done on sharing so openly and getting through it in a public forum. i am into the recovery phase but still looking dreadful and I wasn't brave enough to do photos even though I blogged about it at the start of the treatment. I'm trying to restrain myself from scratching layers off but desperate to see if the 'new skin' underneath will be clear. if not, surgery will be next....

Layo on April 16, 2012:

Read your page before I embarked on this. thank you so much for sharing everything. I'm on day 11 now and so far it's not too bad. Bit concerned that I'm away from Australia and UK doctor is not familiar with this. Was told originally to use for 21 days, but if it's bad, when will I know it's ok to stop? It's just up to me to decide. Help!

Patricia calvert on February 22, 2012:

Thank You for sharing your experence.I have started to use Efudix and felt concerned with itching inflamation and blistering but have decided to carry on after reading your Article

Nancy Hamer on May 13, 2011:

Thank you for your article, it was most informative. My skin specialist recommended this traetment and your journey was the most insightful of all my searches.

COURTNEY FREEMAN (Mr) on January 13, 2011:

What a brilliant article. It just happens that today is number 16 and I had decided to stop applying Efudix for a few days as my condition appeared to be getting no better and pretty unbearable. My doctor had actually advised to apply cream for 4 weeks and no other advice was given. I too was wary of not applying Efudix for long enough but now skin has started to peel and the new skin is wet but very smooth, which I thought might be news. Reading your article has put my mind to rest and am happy to start the recovery phase. I think that an explanation leaflet given by the doctor may have been a good idea.

Linda on October 12, 2010:

Well done Kirsty it's tough but worth it. I was a fair freckled child raised for 6 years in Africa and have been having treatment for over 20 years. I am on Efudix day 6 recovery and smiling is so much easier - vaseline is my saviour! You look great, stay strong:empathy with you, Neville and all the others out there. Thanks for sharing it really helps. Linda x

Neville on October 08, 2010:

Congrats Kirstie I too am on the Efudix journey. I started the treatment on the 1st of August 2010 and was told to keep putting the cream on until it (my face x2 daily) was all gone by my doctor. Today is October 8th 2010 and I have read just about all I can today about this cream. This morning will be the last time I apply this cream. I sympathize with you the whole way. Stay strong. Thanks for sharing

Sharon Neish on September 30, 2010:

Your new skin looks amazing Kirsty! I couldn't imagine the pain you've endured. All for a positive result. Thanks for sharing X Sharon X

Tammy on September 29, 2010:

Thank you for sharing your story Kirstie, you are very brave.

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